Agathisflavone, a natural biflavonoid that inhibits SARS-CoV-2 replication by targeting its proteasesArticle Published on 2022-12-012022-11-15 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome AGT Anacardium Analysis anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral antiviral drug apigenin Biflavonoid biological activity Calu-3 Cell clinical benefit coronavirus COVID-19 dose-dependent manner humoral immune response indicated inhibit investigated Lineage M pro monomer Papain-like protease pro-inflammatory protease SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2. Structure susceptible TNF-α tumor necrosis factor-alpha Type II pneumocyte Vaccines variants of concern [DOI] 10.1016/j.ijbiomac.2022.09.204 PMC 바로가기
Zinc pyrithione is a potent inhibitor of PL Pro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication아연 피리티온은 SARS-CoV-2 진입 및 복제를 생체 외에서 억제하는 PL Pro 및 카텝신 L 효소의 강력한 억제제입니다.Article Published on 2022-12-012022-09-11 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] COVID19(2023년), SARS, 치료제, [키워드] analogue Anti-SARS-CoV-2 Activity Antiviral antiviral activity Antiviral agents assays cathepsin L comparable complex complexes contrary COVID-19 effective enzyme Enzymes evaluated Ex vivo expressed human lung tissue in vitro inhibition inhibitor involved Ligand media Pro pyrithione Replication ruthenium SARS-CoV-2 SARS-CoV-2 entry stability synthesised therapeutic therapeutic agent Zinc Zinc complexes Zinc pyrithione zinc. [DOI] 10.1080/14756366.2022.2108417 PMC 바로가기 [Article Type] Article
Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] aggravation ameliorated anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Antiviral antiviral activity cationic caused cell lines characterization cholesterol complex Compound compounds COVID-19 pandemic COVID-19 patient cytopathic Cytopathic effect Drug discovery effective envelope envelope proteins epiandrosterone followed by hACE2 HEK293 host cell host cells identification in vitro in vivo indicated inhibited initial involved life Lipid mechanism membrane modulate modulation Mortality Pathogenesis progeny protective effect Protective effects Proteins Quality of life reduce reduce COVID-19 aggravation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected Selection single mutation single mutations specific treatment spike steroidal compounds. subversion Transgenic mouse translate transmembrane Treatment treatment of COVID-19 patients Vero Vero CCL81 cell Vero CCL81 cells viral replication Viral RNA viral variant Viral variants [DOI] 10.1080/21505594.2022.2085793 PMC 바로가기 [Article Type] Article
Structural Reshaping of the Zinc-Finger Domain of the SARS-CoV-2 nsp13 Protein Using Bismuth(III) Ions: A Multilevel Computational StudyArticle Published on 2022-10-032022-11-16 Journal: Inorganic chemistry [Category] COVID19(2023년), SARS, 변종, [키워드] analyses anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity classical decrease degrade domain Effect Efficacy Evidence evidenced extension feature Helicase hydrophobic immune Interaction Ion MD simulations MIF Modification molecular molecular interaction non-structural protein nsp12 protein nsp13 Occurrence pandemic Protein provide Research responsible SARS-COV-2 infection the SARS-CoV-2 the vaccine therapeutic strategy variants [DOI] 10.1021/acs.inorgchem.2c02685 PMC 바로가기
In Silico Study towards Repositioning of FDA-Approved Drug Candidates for Anticoronaviral Therapy: Molecular Docking, Molecular Dynamics and Binding Free Energy CalculationsArticle Published on 2022-09-142022-11-15 Journal: Molecules [Category] SARS, 신약개발, 치료제, [키워드] AAK1 addition Anti-COVID-19 Anti-SARS-CoV-2 Activity applied binding binding free energy binding pattern calculation candidate Combination complexes computational modeling digoxin drug drug repositioning drugs Dynamics energy Enzymes evaluated exhibited FDA-approved drug Free greater in silico inhibitor inhibitors methodology molecular molecular docking molecular dynamic simulations. MPro niclosamide ouabain PLPro Proscillaridin protease Protein provide RdRP repositioning RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 main protease screened suggested target targets tested to define [DOI] 10.3390/molecules27185988 PMC 바로가기
The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variantsArticle Published on 2022-09-072022-10-06 Journal: Science Translational Medicine [Category] SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome Administered Anti-SARS-CoV-2 Activity antiviral drug antiviral efficacy antiviral potency coronavirus coronavirus disease COVID-19 delta variant demonstrated driving Efficacy exhibited GS-441524 in vitro K18-hACE2 mice lung damage Mouse models oral administration oral bioavailability pandemic parent nucleoside parental prophylactically reduced viral load Remdesivir SARS-CoV-2 SARS-CoV-2 transmission vaccination variant variants of concern virus VoC VOCs [DOI] 10.1126/scitranslmed.abm7621 PMC 바로가기 [Article Type] Article
Structures, biomimetic synthesis, and anti-SARS-CoV-2 activity of two pairs of enantiomeric phenylpropanoid-conjugated protoberberine alkaloids from the rhizomes of Corydalis decumbensArticle Published on 2022-09-012022-11-15 Journal: Archives of pharmacal research [Category] SARS, 치료제, [키워드] ACE2 receptor analyses Analysis anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral binding Biomimetic synthesis biosynthetic Compound Corydalis Corydalis decumbens COVID-19 ECD exhibited ferulic acid host cells HPLC Isoquinoline alkaloid. Pathways purified SARS-CoV-2 pseudovirus Structure X-ray [DOI] 10.1007/s12272-022-01401-6 PMC 바로가기
Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2′-O-ribose methyltransferasesArticle Published on 2022-09-012022-11-15 Journal: The EMBO Journal [Category] COVID19(2023년), SARS, 치료제, [키워드] AHCY Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral drug antivirals attenuation Concomitant COVID-19 COVID-19 treatments Drug screening DZNep enzyme Ex vivo exhibit functional Host host-directed hyperinflammation identify Immune escape immunomodulatory effect in silico in vitro in vivo independent Infection Inflammation inhibitor Interaction Lung fibrosis marker Methylation methyltransferase methyltransferase. pathogen reduce SAM SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Side effects Stage suppresse Treatment Viral RNA virus replication [DOI] 10.15252/embj.2022111608 PMC 바로가기
The effect of ivermectin on the viral load and culture viability in early treatment of nonhospitalized patients with mild COVID-19 – a double-blind, randomized placebo-controlled trialRandomized Controlled Trial Published on 2022-09-012022-10-04 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 신약개발, 임상, 치료법, 치료제, [키워드] 95% confidence interval Anti-SARS-CoV-2 Activity antiparasitic antiviral properties COVID-19 Culture cultures cycle threshold double-blind double-blinded early treatment Endpoint evaluated Infectivity Infectivity duration Ivermectin ivermectin group less Mild multivariable logistic regression Nasopharyngeal swab negative test Odds ratio Patient patients with COVID-19 per-protocol Placebo positive primary endpoint Primary outcome randomized placebo-controlled trial reached receiving recruitment reduce reduction reflected SARS-CoV-2 screened supported the placebo group Transmission Trial viability viral cultures Viral cultures. Viral load was obtained [DOI] 10.1016/j.ijid.2022.07.003 PMC 바로가기 [Article Type] Randomized Controlled Trial
A potent virucidal activity of functionalized TiO2 nanoparticles adsorbed with flavonoids against SARS-CoV-2Article Published on 2022-09-012022-11-15 Journal: Applied Microbiology and Biotechnology [Category] SARS, 치료제, [키워드] ACE-2 ACE-2 receptor Adsorption angiotensin-converting enzyme-2 Anti-SARS-CoV-2 Activity antiviral activity Antiviral effect antivirals binding block caused Cell Cell culture cell entry coronavirus SARS-CoV-2 COVID-19 Critical death demonstrated develop displaying Effect event Flavanone-7-O-glucoside flavonoid HCoV 229E Hesperetin-7-rutinoside host cell impair impairing imperative in vitro induce interact Interaction interfere management mechanism mental health molecular docking analysis Nanoparticulate compound pandemic receptor Region SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike glycoprotein. spike glycoprotein Spread supportive care targeted therapy the SARS-CoV-2 viral infection virucidal [DOI] 10.1007/s00253-022-12112-9 PMC 바로가기